oncology-db-mcp

# OncologyDB MCP Server English | [中文](README.zh.md) > Give your AI assistant the ability to query precision oncology data — gene targets, FDA-approved drugs, clinical trials, and treatment evidence. An [MCP](https://modelcontextprotocol.io) server integrating [CIViC](https://civicdb.org), [OpenFDA](https://open.fda.gov), and [ClinicalTrials.gov](https://clinicaltrials.gov). Covers **563 gene targets**, **9,500+ oncology drugs**, and **18,000+ clinical trials**. ## Installation ### Claude Code ```bash claude mcp add --transport http -s user oncology-db https://oncodb.zhiyudao.cn/mcp/mcp ``` Restart Claude Code. Done. ### Claude Desktop / Cursor / Windsurf Add to your MCP config: ```json { "mcpServers": { "oncology-db": { "url": "https://oncodb.zhiyudao.cn/mcp/mcp" } } } ``` ## What Can It Do Once installed, just ask your AI assistant in natural language: ### Query Target Treatments - "What are the treatment options for KRAS G12C?" - "Which FDA-approved drugs target EGFR L858R?" - "Show me resistance evidence for BRAF V600E" ### Look Up Drug Details - "What is the mechanism of action of Sotorasib?" - "What indications is Pembrolizumab approved for?" - "How many recruiting clinical trials involve Osimertinib?" ### Search Clinical Trials - "Find recruiting Phase 3 trials for KRAS G12C" - "Are there any new drug trials for ALK fusions?" ### Get Guideline Recommendations - "What does CIViC assert about BRAF V600E in melanoma?" - "Show NCCN guideline recommendations for EGFR mutations" ## Tools | Tool | Description | |------|-------------| | `search` | Search by gene name, drug name, or disease | | `get_target_treatments` | All treatments for a gene-variant target (auto-separates sensitivity vs resistance) | | `get_drug_detail` | Drug details: FDA status, mechanism of action, indications, clinical trials | | `list_genes` | List all gene targets with evidence counts | | `get_gene_variants` | List all variants for a specific gene | | `search_trials` | Search clinical trials by keyword, status, phase | | `get_stats` | Database statistics | | `get_civic_assertions` | CIViC clinical assertions (regulatory approvals, guideline recommendations) | ## Clinical Accuracy Safeguards - **Sensitivity vs resistance separation** — "Supports Resistance" evidence is never shown as a positive treatment option - **Combination therapy context** — Clinical-grade (A/B level) combination regimens are labeled (e.g., Cetuximab + Adagrasib) - **Drug type classification** — Targeted therapy / Chemotherapy / Immunotherapy / ADC - **Evidence grading** — CIViC evidence levels A through E - **Non-drug entity filtering** — Excludes drug class names like "BRAF Inhibitor" or "Chemotherapy" from drug results ## Data Sources | Source | Content | |--------|--------| | [CIViC](https://civicdb.org) | 11,232 clinical evidence records + 213 assertions + 1,967 variants | | [OpenFDA](https://open.fda.gov) | 50,939 FDA drugs + 256,165 drug labels | | [ClinicalTrials.gov](https://clinicaltrials.gov) | 18,161 oncology clinical trials | ## Web Interface A web UI for interactive browsing is also available at https://oncodb.zhiyudao.cn ## Disclaimer This tool is for research reference only and does not constitute medical advice. Clinical decisions should be made in consultation with qualified healthcare professionals. ## License MIT ## Feedback Issues and pull requests: https://github.com/CancerDAO/oncology-db-mcp